Journal article
Fiber-Specific Measures of White Matter Microstructure and Macrostructure Are Associated With Internalizing and Externalizing Symptoms in Children Born Very Preterm and Full-term
CP Gilchrist, CE Kelly, A Cumberland, T Dhollander, K Treyvaud, K Lee, JLY Cheong, LW Doyle, TE Inder, DK Thompson, M Tolcos, PJ Anderson
Biological Psychiatry | Published : 2023
Abstract
Background: Tensor-based investigations suggest that delayed or disrupted white matter development may relate to adverse behavioral outcomes in individuals born very preterm (VP); however, metrics derived from such models lack specificity. Here, we applied a fixel-based analysis framework to examine white matter microstructural and macrostructural correlates of concurrent internalizing and externalizing problems in VP and full-term (FT) children at 7 and 13 years. Methods: Diffusion imaging data were collected in a longitudinal cohort of VP and FT individuals (130 VP and 29 FT at 7 years, 125 VP and 44 FT at 13 years). Fixel-based measures of fiber density, fiber-bundle cross-section, and fi..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
This study was supported in part by an Australian Government Research Training Program Scholarship (to CPG and CK); the Australian National Health and Medical Research Council (Center for Clinical Research Excellence (Grant Nos. 546519, 1060733, and 1153176); Project Grant (Grant Nos. 237117, 491209, and 1066555); Career Development Fellowships 1085754 and 1160003 [to DKT] and 1141354 [to JLYC]; Early Career Fellowship 1012236 [to DKT]; and Senior Research Fellowship 1081288 and Leadership Fellowship 1176077 [to PJA]); Financial Markets Foundation for Children Project Grant (Grant No. 2019-083 [to AC, PJA, DKT, MT]); RMIT Vice Chancellor's Senior Research Fellowship and Australian Research Council Future Fellowship (to MT); U.S. National Institutes of Health (Grant No. HD058056); Murdoch Children's Research Institute; the Royal Children's Hospital; The Royal Children's Hospital Foundation; Department of Paediatrics, The University of Melbourne; and the Victorian Government's Operational Infrastructure Support Program.